Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Temperature- and pH-responsive smart polymers for gene delivery.

Cameron Alexander1

  • 1The School of Pharmacy, Boots Science Building, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. cameron.alexander@nottingham.ac.uk

Expert Opinion on Drug Delivery
|September 5, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Telehealth Diagnostic Tool for Autistic Children With Phrased and Fluent Speech: Comparison to In-person Diagnosis.

Journal of autism and developmental disorders·2026
Same author

Engineering immunostimulatory nanocarriers: TLR7-agonist conjugated poly(beta-amino ester) mRNA delivery systems.

Biomaterials science·2026
Same author

The evolutionary transition from intentional to overt communication: The role of script recognition.

Psychological review·2026
Same author

Modular Supramolecular Polycations Enable Efficient Delivery of Diverse RNA Therapeutics and Vaccines.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Intraoperative drug delivery to hindbrain tumours via an injectable hydrogel is well tolerated and confers survival benefit against atypical teratoid/rhabdoid xenografts.

Drug delivery and translational research·2026
Same author

Poly(beta-amino esters): applications in immunology.

Chemical science·2025
Same journal

Response to letter to the Editor 'saving money but costing lives: the lack of integrated dose counters on pressurised metered dose inhalers'.

Expert opinion on drug delivery·2026
Same journal

Mechanism-guided metal complex therapeutics for biofilm-driven wound infections and transdermal delivery.

Expert opinion on drug delivery·2026
Same journal

Next-generation strategies for PROTAC formulation: mechanistic insights and advanced formulation technologies.

Expert opinion on drug delivery·2026
Same journal

Drug penetration in solid tumors: influence of drug size and capillary architecture.

Expert opinion on drug delivery·2026
Same journal

Beyond bioequivalence: a critical overview of the innovator AmBisome as the reference standard for liposomal amphotericin B generics.

Expert opinion on drug delivery·2026
Same journal

Hydrogel-based drug delivery systems for oral mucositis: a systematic review of preclinical models and translational perspectives.

Expert opinion on drug delivery·2026
See all related articles

Next-generation biopolymer therapeutics, particularly nucleic acids, require advanced biomaterials for effective gene delivery. Responsive polymers offer a promising solution for protecting and releasing genetic material at target sites.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanomedicine

Background:

  • Biopolymer therapeutics, especially nucleic acids, represent a future frontier in medicine.
  • Efficient gene delivery faces significant challenges, necessitating advanced biomaterials.

Purpose of the Study:

  • To review the chemistries of responsive polymers for gene delivery.
  • To outline mechanisms for nucleic acid protection and release.
  • To highlight advanced multicomponent polymers for overcoming gene delivery barriers.

Main Methods:

  • Review of responsive polymer chemistries (temperature, pH).
  • Analysis of nucleic acid interaction and release mechanisms.
  • Highlighting examples of sophisticated multicomponent polymers.

Related Experiment Videos

Main Results:

  • Responsive polymers can modulate interactions with nucleic acid payloads.
  • Multicomponent polymers are engineered to address systemic and local gene delivery barriers.
  • These materials show potential for advanced therapies beyond gene delivery.

Conclusions:

  • Stimulus-responsive polymers are key candidates for advanced gene delivery vehicles.
  • Engineered polymers are crucial for overcoming current gene delivery limitations.
  • Emerging applications include cell delivery and regenerative medicine.