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Related Concept Videos

Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Time-controlled oral delivery systems for colon targeting.

Andrea Gazzaniga1, Alessandra Maroni, Maria Edvige Sangalli

  • 1Istituto di Chimica Farmaceutica e Tossicologica P. Pratesi, Università di Milano, V.le Abruzzi 42, 20131 Milan, Italy. andrea.gazzaniga@unimi.it

Expert Opinion on Drug Delivery
|September 5, 2006
PubMed
Summary

Achieving targeted drug delivery to the colon via oral administration is crucial for treating bowel diseases and improving the bioavailability of biologics. Time-controlled release devices offer a promising strategy for colonic drug delivery.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Gastrointestinal Pharmacology

Background:

  • Selective drug delivery to the colon is essential for treating widespread large bowel pathologies like inflammatory bowel disease and adenocarcinoma.
  • Colonic drug delivery enhances the oral bioavailability of peptides and proteins by minimizing enzymatic degradation in the large intestine compared to the small intestine.

Purpose of the Study:

  • To review the design features and release performance of time-controlled drug delivery devices for colonic administration.
  • To highlight the potential of time-controlled systems for targeted colonic therapies and improved bioavailability of biologics.

Main Methods:

  • Review of existing literature on colonic drug delivery formulations.
  • Analysis of time-controlled release technologies based on consistent small intestinal transit times.
  • Evaluation of formulation strategies including microflora-, pH-, pressure-, and time-dependent systems.

Main Results:

  • Time-controlled release devices are a key strategy for achieving colonic drug delivery.
  • These devices leverage the predictable transit time of dosage forms through the small intestine.
  • Various formulation approaches exist, with time-controlled systems showing significant promise.

Conclusions:

  • Time-controlled drug delivery systems are effective for targeted colonic release.
  • These formulations are beneficial for treating colonic diseases and enhancing the delivery of sensitive biomolecules.
  • Further development in time-controlled devices can optimize colonic drug therapy.