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Updated: Jul 20, 2026
07:50
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Phospho-Stat3 expression and correlation with VEGF, p53, and Bcl-2 in gastric carcinoma using tissue microarray
Jung-Hye Choi1, Myung-Ju Ahn, Chan-Kum Park
1Department of Internal Medicine, Hanyang University, 50 Ilwon-Dong, Gangnam-Gu, Seoul 135-710, Korea.
APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|September 5, 2006
Summary
Signal transducer and activator of transcription 3 (Stat3) activation in gastric cancer correlates with VEGF and Bcl-2, suggesting roles in angiogenesis and anti-apoptosis. However, its direct impact on patient survival remains unclear.
Area of Science:
- Oncology
- Molecular Biology
- Cell Signaling
Background:
- Signal transducer and activator of transcription (Stat) proteins are key in cellular signaling pathways.
- Constitutive activation of Stat proteins, particularly Stat3, is observed in various cancers.
- The specific role of Stat3 signaling in gastric carcinoma requires further elucidation.
Purpose of the Study:
- To investigate the clinical significance of phospho-Stat3 expression in gastric carcinoma.
- To evaluate the association between phospho-Stat3, vascular endothelial growth factor (VEGF), p53, and Bcl-2.
- To correlate protein expression with clinicopathological factors and patient survival.
Main Methods:
- Immunohistochemical staining of tissue microarrays from 137 gastric cancer specimens.
- Assessment of phospho-Stat3 (Tyr705), VEGF, p53, and Bcl-2 expression.
- Statistical analysis of protein expression correlations and clinicopathological parameters.
Main Results:
- Phospho-Stat3 nuclear expression was found in 18.2% of gastric cancer cases.
- Phospho-Stat3 expression correlated significantly with VEGF (p=0.021) and Bcl-2 (p=0.005) expression.
- Positive phospho-Stat3 staining was associated with poor pathological grade but not overall survival.
Conclusions:
- Phospho-Stat3 expression in gastric cancer may be linked to angiogenesis and anti-apoptotic processes.
- Co-expression of phospho-Stat3 and VEGF was noted in advanced disease stages (N3, Stage IV).
- Further research is warranted to fully define the role of phospho-Stat3 in gastric cancer pathogenesis and progression.
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