Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Risperidone in children with autism: randomized, placebo-controlled, double-blind study.

Ravishankar Nagaraj1, Pratibha Singhi, Prahbhjot Malhi

  • 1Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, India 160012.

Journal of Child Neurology
|September 5, 2006
PubMed
Summary

Risperidone significantly improved functioning in children with autism, reducing aggression and hyperactivity. This autism treatment was well-tolerated, enhancing social and communication skills.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post Diphtheritic Paralysis in an Unimmunised Child: Authors' Reply.

Indian journal of pediatrics·2026
Same author

Clinical, Neuroimaging, and Functional Profile of Children With Hemiplegic Cerebral Palsy: A Cross-Sectional Study From a Tertiary Care Center.

Journal of child neurology·2026
Same author

Diagnosis and management guidelines for infantile epileptic spasms syndrome around the world: A scoping review and comparative study of international approaches.

Epilepsia·2026
Same author

Headache in a Young Child Revealing an Unexpected Intracranial Tumor.

Indian journal of pediatrics·2026
Same author

Association of Screen Media Time with Developmental Outcomes of Children 18 to 24 Months of Age: An Observational Study.

Indian journal of pediatrics·2026
Same author

Post Diphtheritic Paralysis in an Unimmunised Child.

Indian journal of pediatrics·2026

Area of Science:

  • Pediatric Psychiatry
  • Neurodevelopmental Disorders
  • Pharmacological Interventions

Background:

  • Open-label studies suggest risperidone's efficacy in treating target symptoms in children with autism.
  • A need exists to rigorously evaluate risperidone's impact on core autism symptoms and overall functioning.

Purpose of the Study:

  • To assess the efficacy of risperidone compared to placebo in improving behavioral, social, emotional, and communication skills in children with autism.
  • To evaluate the impact of risperidone on Childhood Autism Rating Scale (CARS) and Children's Global Assessment Scale (CGAS) scores.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving 40 children aged 2-9 years with autism.
  • Participants received either risperidone (1 mg/day) or placebo orally for 6 months.

Related Experiment Videos

  • Autism symptoms were monitored, with CARS and CGAS scores as primary outcome variables.

    • Main Results:

    • 12/19 children on risperidone improved CARS scores versus 0/20 on placebo (P < .001).
    • 17/19 children on risperidone improved CGAS scores versus 2/20 on placebo (P = .035).
    • Risperidone enhanced social responsiveness, nonverbal communication, and reduced hyperactivity and aggression.

    Conclusions:

    • Risperidone significantly improved global functioning and social responsiveness in children with autism.
    • The medication was well-tolerated, with common side effects including increased appetite, mild weight gain, sedation, and transient dyskinesias.
    • Risperidone demonstrates a favorable risk-benefit profile for managing specific symptoms in pediatric autism.