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Childhood mesial temporal sclerosis
Yu-tze Ng1, Amy L McGregor, Dawn C Duane
1Division of Child Neurology, St. Joseph's Hospital and Children's Health Center at Barrow Neurological Institute, 500 West Thomas Road, Phoenix, AZ 85013, USA. y2ng@chw.edu
Journal of Child Neurology
|September 5, 2006
Summary
Mesial temporal sclerosis is uncommon in children, affecting 0.77% of pediatric brain MRI studies. When present, it is always associated with epilepsy, often following febrile seizures.
Area of Science:
- Neurology
- Pediatric Radiology
- Epileptology
Background:
- Mesial temporal sclerosis (MTS) prevalence and clinical features in children are not well-documented.
- Pediatric epilepsy diagnosis often relies on neuroimaging, including MRI.
- Understanding MTS in pediatric populations is crucial for accurate diagnosis and management.
Purpose of the Study:
- To determine the prevalence of mesial temporal sclerosis in children.
- To describe the clinical characteristics of pediatric patients diagnosed with MTS.
- To investigate the association between MTS and seizure disorders in children.
Main Methods:
- Retrospective review of brain MRI reports for children under 14 years from two tertiary institutions.
- Inclusion criteria: definite or possible mesial temporal sclerosis on MRI.
- Confirmation of MRI diagnostic criteria for MTS and detailed chart review of confirmed cases.
Main Results:
- 3,100 pediatric brain MRI reports were reviewed.
- 24 out of 26 identified cases met the MRI criteria for mesial temporal sclerosis.
- The prevalence of MTS among pediatric brain MRI studies was 0.77%.
- All identified patients presented with seizures; no incidental findings of MTS were observed.
- Four patients had a history of febrile seizures.
Conclusions:
- Mesial temporal sclerosis is an uncommon finding in children.
- MTS in pediatric patients is consistently associated with epilepsy.
- Asymptomatic MTS or MTS without a seizure disorder was not observed in this series.
- Febrile seizures may be associated with childhood-onset MTS.
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