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Related Experiment Videos

Childhood mesial temporal sclerosis.

Yu-tze Ng1, Amy L McGregor, Dawn C Duane

  • 1Division of Child Neurology, St. Joseph's Hospital and Children's Health Center at Barrow Neurological Institute, 500 West Thomas Road, Phoenix, AZ 85013, USA. y2ng@chw.edu

Journal of Child Neurology
|September 5, 2006
PubMed
Summary
This summary is machine-generated.

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Mesial temporal sclerosis is uncommon in children, affecting 0.77% of pediatric brain MRI studies. When present, it is always associated with epilepsy, often following febrile seizures.

Area of Science:

  • Neurology
  • Pediatric Radiology
  • Epileptology

Background:

  • Mesial temporal sclerosis (MTS) prevalence and clinical features in children are not well-documented.
  • Pediatric epilepsy diagnosis often relies on neuroimaging, including MRI.
  • Understanding MTS in pediatric populations is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To determine the prevalence of mesial temporal sclerosis in children.
  • To describe the clinical characteristics of pediatric patients diagnosed with MTS.
  • To investigate the association between MTS and seizure disorders in children.

Main Methods:

  • Retrospective review of brain MRI reports for children under 14 years from two tertiary institutions.
  • Inclusion criteria: definite or possible mesial temporal sclerosis on MRI.

Related Experiment Videos

  • Confirmation of MRI diagnostic criteria for MTS and detailed chart review of confirmed cases.

    • Main Results:

    • 3,100 pediatric brain MRI reports were reviewed.
    • 24 out of 26 identified cases met the MRI criteria for mesial temporal sclerosis.
    • The prevalence of MTS among pediatric brain MRI studies was 0.77%.
    • All identified patients presented with seizures; no incidental findings of MTS were observed.
    • Four patients had a history of febrile seizures.

    Conclusions:

    • Mesial temporal sclerosis is an uncommon finding in children.
    • MTS in pediatric patients is consistently associated with epilepsy.
    • Asymptomatic MTS or MTS without a seizure disorder was not observed in this series.
    • Febrile seizures may be associated with childhood-onset MTS.