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[A randomized single-blind trial of the effects of vitamins C and E in familial hypercholesterolemia]

L Aldámiz-Echevarría1, J Dalmau, J A Prieto

  • 1Departamento de Pediatría, División de Metabolismo, Hospital de Cruces y Facultad de Medicina de la Universidad del País Vasco, Baracaldo, España. kaldamiz@hcru.osakidetza.net

Anales De Pediatria (Barcelona, Spain : 2003)
|September 5, 2006
PubMed

Insights

Antioxidant vitamin C and E therapy in children with familial hypercholesterolemia (FH) improved fatty acid profiles, potentially reducing cardiovascular risk. These changes occurred independently of cholesterol levels.

Area of Science:

  • Biochemistry
  • Pediatric Cardiology
  • Nutritional Science

Context:

  • Familial hypercholesterolemia (FH) is a genetic disorder causing high LDL-cholesterol.
  • Children with heterozygous FH require effective management strategies.
  • Dyslipidemia and inflammation are key risk factors for cardiovascular disease in FH.

Purpose:

  • To assess the impact of antioxidant vitamins C and E on lipid profiles, fatty acid composition, and inflammatory markers in children with heterozygous FH.
  • To investigate whether vitamin supplementation alters biochemical markers associated with cardiovascular risk in this pediatric population.

Summary:

  • A 1-year randomized trial involved 40 children with heterozygous FH, comparing vitamin C and E supplementation against a control group.
  • Supplementation led to increased plasma linoleic acid (18:2 omega-6) and decreased essential fatty acid deficiency ratio.
  • No significant changes were observed in lipid profiles, adhesion molecules, or C-reactive protein.

Impact:

  • Antioxidant vitamin therapy can positively modify plasma fatty acid profiles in children with FH.
  • These alterations in fatty acid composition may serve as a biomarker for reduced cardiovascular risk.
  • The findings suggest a potential adjunctive role for antioxidants in managing pediatric FH.
Abstract

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