Related Experiment Videos
Aberrant gene expression and aging: examination of tissue-specific mRNAs in young and old rats
A I Sato1, E L Schneider, D B Danner
1Laboratory of Molecular Genetics, National Institute on Aging, Baltimore, MD 21224.
Mechanisms of Ageing and Development
|May 15, 1990
Abstract:
It has been suggested that aberrant gene expression may play a role in aging. To test this possibility, we examined the steady-state mRNA levels for five tissue-specific genes of known function in young (6 month) and old (24 month) rats. Six different tissues from three animals of each age were analyzed using a hybridization assay estimated to be able to detect one mRNA copy per cell. At this level of sensitivity, no aberrant gene expression was seen. The results indicate that these tissue-specific genes retain their fidelity of expression with age.