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Updated: Jul 20, 2026

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
Published on: October 28, 2022
Erythropoietin and acute renal failure
Edward J Sharples1, Muhammad M Yaqoob
1Center for Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary, University of London, London, UK. edsharps@doctors.org.uk
Abstract:
The hemopoietic growth factor erythropoietin (EPO) has been recognized to be a multifunctional cytokine that plays a key role in ischemic preconditioning in the brain and heart. The EPO receptor is expressed widely in the kidney, and we review the important findings from the use of EPO in experimental models of acute renal failure that show that EPO reduces tubular cell death and hence the dysfunction induced by ischemia reperfusion injury, and we explore how these observations may be translated into the clinical arena.
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