Related Experiment Video
Updated: Jul 20, 2026

Assessing Intracardiac Vortices with High Frame-Rate Echocardiography-Derived Blood Speckle Imaging in Newborns
Published on: December 22, 2023
Atrial flutter in infants
Karen M Texter1, Naomi J Kertesz, Richard A Friedman
1Department of Pediatrics, Division of Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA. kmtexter@texaschildrenshospital.org
Insights
Infants with atrial flutter (AFL) typically present early in life and often resolve spontaneously or with cardioversion. AFL in infants without other arrhythmias has a low recurrence risk and an excellent prognosis once in sinus rhythm.
Area of Science:
- Pediatric Cardiology
- Electrophysiology
- Neonatal Medicine
Background:
- Limited large-scale studies exist on the natural history of atrial flutter (AFL) in infants.
- Previous research on infant AFL has shown variability in treatment approaches and expected outcomes.
Purpose of the Study:
- To characterize the clinical presentation and outcomes of atrial flutter (AFL) in a large cohort of infants.
- To evaluate the effectiveness of different treatment modalities for infant AFL.
- To assess the long-term prognosis for infants diagnosed with AFL.
Main Methods:
- Retrospective review of medical records for infants under 1 year diagnosed with AFL over 25 years.
- Exclusion criteria included prior cardiac surgery.
- Data collected on presentation, clinical findings, interventions, and outcomes.
Main Results:
- Fifty infants were diagnosed with AFL, with 72% presenting within 48 hours of birth.
- Congestive heart failure occurred in 10 infants; 26% experienced spontaneous conversion to sinus rhythm.
- Direct current cardioversion was highly effective (87%) in restoring sinus rhythm, while transesophageal pacing was less effective (32%).
Conclusions:
- Infant atrial flutter commonly presents within the first two days of life and is not associated with structural heart disease.
- Direct current cardioversion is the most effective method for achieving sinus rhythm in infants with AFL.
- Infants with AFL, particularly those without other arrhythmias, have an excellent prognosis and may not require long-term antiarrhythmic therapy after achieving sinus rhythm.
Objectives:
We sought to characterize the clinical nature of atrial flutter (AFL) in a large cohort of infants.
Background:
There are no large studies describing the natural history of AFL in infants. Previous studies vary in the therapy used and expected prognosis.
Methods:
We reviewed the records of all children younger than 1 year of age who were diagnosed with AFL at our hospital during the past 25 years, excluding those with previous cardiac surgery.
Results:
We identified 50 infants with AFL. Most, 36 (72%), presented within the first 48 h of life. Congestive heart failure was evident in 10 infants, with 6 presenting at 1 day of age, and 4 presenting beyond 1 month of age. The remainder were asymptomatic. A large atrial septal defect was the only structural heart disease. Spontaneous conversion to sinus rhythm occurred in 13 (26%) infants. Sinus rhythm was restored in 20 of 23 (87%) attempts at direct current cardioversion and 7 of 22 (32%) attempts at transesophegeal pacing; 7 required antiarrhythmic therapy. An additional arrhythmia, all supraventricular, appeared in 11 (22%) infants. The recurrence of AFL developed in 6 infants; 5 of 6 of these incidents occurred within 24 h of the first episode. All patients with recurrence had an additional arrhythmia.
Conclusions:
Infants with AFL usually present within the first 2 days of life. No association was found with structural heart disease. Direct current cardioversion appears to be most effective at establishing sinus rhythm. Chronic AFL has the potential to cause cardiovascular compromise. Atrial flutter in the absence of other arrhythmias has a low risk of recurrence. Once in sinus rhythm, infants with AFL have an excellent prognosis and may not require chronic antiarrhythmic therapy.
Related Concept Videos
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Dysrhythmias III: Characteristics of Dysrhythmias
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Dysrhythmias II: Classification of Tachyarrhythmias
Chambers of the Heart
Deoxygenated blood from the body is received in the right...

