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Microbubble-enhanced hemorrhage control using high intensity focused ultrasound
Vesna Zderic1, Andrew A Brayman, Sam R Sharar
1Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. vesna@u.washington.edu <vesna@u.washington.edu>
Ultrasonics
|September 5, 2006
Summary
Adding ultrasound contrast agents (UCA) significantly speeds up hemorrhage control using high-intensity focused ultrasound (HIFU). This method enhances coagulum seal formation, offering faster treatment for solid organ injuries.
Area of Science:
- Medical Devices
- Ultrasound Technology
- Surgical Innovation
Background:
- Hemorrhage control in solid organ injuries remains a clinical challenge.
- High-intensity focused ultrasound (HIFU) is an emerging technology for tissue ablation and hemostasis.
- Ultrasound contrast agents (UCA) are known to enhance ultrasound imaging and therapeutic effects.
Purpose of the Study:
- To evaluate the efficacy of combining high-intensity focused ultrasound (HIFU) with ultrasound contrast agents (UCA) for faster hemorrhage control.
- To compare hemostasis times using HIFU with and without UCA in a rabbit liver injury model.
Main Methods:
- Surgical incisions were created in rabbit livers under anesthesia.
- High-intensity focused ultrasound (HIFU) was applied to the incisions.
- Ultrasound contrast agent (Optison) was administered intravenously in one group.
- Hemostasis times and coagulum seal formation were measured and compared between groups.
Main Results:
- HIFU application in the presence of UCA resulted in significantly reduced hemostasis times (59±23 s) compared to HIFU alone (70±23 s).
- UCA demonstrated a 37% reduction in hemostasis times normalized to initial bleeding rates.
- A 60% faster formation of the coagulum seal was observed when UCA were used with HIFU.
- Histological examination revealed no significant differences in HIFU-induced lesion appearance between the groups.
Conclusions:
- Ultrasound contrast agents (UCA) can significantly enhance the speed and efficiency of high-intensity focused ultrasound (HIFU)-induced hemostasis.
- The combination of HIFU and UCA shows potential for improving the treatment of solid organ injuries.
- Further research may explore UCA-enhanced HIFU for clinical applications in surgical hemostasis.
