[Possibility of the treatment of tuberculosis with delayed-action polymeric isoniazid]

In vitro destruction of carboxymethylcephades (CMC) polymer, its based polymer isoniazid produced, and the in vivo remedial and long effect of the latter on a tuberculous process were studied. It was found that a polymer isoniazid in blood plasma gradually degraded by 80% within 5-6 days. The experiments on animals demonstrated a minimum reactive action of CMC capable of gradually biodegrading in the tissues. A possible treatment of tuberculosis with a polymer isoniazid administered once every week is shown.