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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Allergic contact dermatitis caused by latanoprost ophthalmic solution
1Department of Ophthalmology, Chang Gung Memorial Hospital-Chiayi, 6 Sec.West, Chia-Pu Road, Putz, Chiayi 61363, Taiwan.
European Journal of Ophthalmology
|September 5, 2006
Summary
Allergic contact dermatitis (ACD) to latanoprost, a glaucoma medication, can manifest as eyelid swelling and redness. Discontinuation and avoidance of latanoprost led to resolution of symptoms in two elderly patients.
Area of Science:
- Ophthalmology
- Dermatology
Background:
- Latanoprost, a prostaglandin F2 alfa analog, effectively lowers intraocular pressure by enhancing uveoscleral outflow.
- It is commonly prescribed for open-angle glaucoma management.
Observation:
- Two elderly male patients with open-angle glaucoma developed distinct eyelid reactions after four months of latanoprost therapy.
- One patient presented with bilateral eyelid erythematous erosive swelling, while the other experienced pruritic erythematous plaques on the lower eyelids.
Findings:
- Discontinuation of latanoprost resulted in gradual resolution of eyelid conditions within one month for both patients.
- Rechallenge with latanoprost provoked recurrence of eyelid lesions within days, confirming allergic contact dermatitis (ACD).
Implications:
- ACD to latanoprost should be considered in elderly patients presenting with eyelid pruritus, erythema, swelling, or erosions.
- Symptoms may arise even after prolonged latanoprost therapy, necessitating careful evaluation and potential drug cessation or substitution.
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