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Updated: Jul 20, 2026

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
Published on: May 2, 2025
Probing structural effects on replication efficiency through comparative analyses of families of potential
Eleftherios Kassianidis1, Russell J Pearson, Douglas Philp
1Centre for Biomolecular Sciences, School of Chemistry, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK.
Abstract:
A formidable synthetic apparatus for the creation of nanoscale molecular structures and supramolecular assemblies through molecular structures can potentially be created from systems that are capable of parallel automultiplication (self-replication). In order to achieve this goal, a detailed understanding of the relationship between molecular structure and replication efficiency is necessary. Diastereoisomeric templates that are capable of specific and simultaneous autocatalysis have been synthesised. A systematic experimental and theoretical evaluation of their behaviour and that of structurally-related systems reveals the key determinants that dictate the emergence of self-replicative function and defines the structural space within which this behaviour is observed.
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