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Updated: Jul 20, 2026
06:25
Coronary Angiography During Ex-Situ Heart Perfusion in a Porcine Model
Published on: July 12, 2024
Routine coronary angiography in diabetic nephropathy patients before transplantation
B J Witczak1, A Hartmann, T Jenssen
1Department of Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Norway. bartlomiej.witczak@rikshospitalet.no
Summary
Diabetic nephropathy patients awaiting kidney transplants often have significant coronary artery stenosis (CAS) without symptoms. Pre-transplant coronary angiography is recommended for these high-risk individuals.
Area of Science:
- Nephrology
- Cardiology
- Transplantation
Background:
- Diabetic nephropathy is a major complication of diabetes, often necessitating kidney transplantation.
- Patients with diabetic nephropathy have a high prevalence of cardiovascular disease, a leading cause of mortality post-transplant.
Purpose of the Study:
- To determine the incidence of significant coronary artery stenosis (CAS) and angina pectoris (AP) in diabetic nephropathy patients.
- To identify risk factors for CAS in this population.
- To evaluate the need for pre-transplant cardiac screening.
Main Methods:
- Retrospective analysis of 155 diabetic nephropathy transplant candidates undergoing coronary angiography.
- Inclusion criteria: diabetes >10 years, retinopathy, or biopsy-proven nephropathy.
- Statistical analysis including multiple logistic regression to identify risk factors.
Main Results:
- 45% of patients had significant CAS; 17% of those had AP.
- Age was the only significant independent risk factor for CAS (p=0.046).
- No significant CAS was found in patients under 35 years old.
- 57% of patients with significant CAS underwent revascularization.
- Most patients with CAS were asymptomatic.
Conclusions:
- A high proportion of diabetic nephropathy transplant candidates have asymptomatic significant coronary artery stenosis.
- Age is a key risk factor for CAS in this cohort.
- Coronary angiography screening before transplantation is warranted for diabetic nephropathy patients.
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