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Updated: Jul 20, 2026
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with
Mirta Knoepfelmacher1, Debora L S Danilovic, Rubia H R Rosa Nasser
1Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM/42, Disciplina de Endocrinologia e Metabologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. mirta@uol.com.br
Objective:
To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.
Design:
Case report.
Setting:
Outpatient practice.
Patient(S):
Two women with menstrual irregularity, enlarged ovaries, high E(2), and normal gonadotropin levels.
Intervention(S):
Cabergoline treatment and transsphenoidal surgery.
Main Outcome Measure(S):
Estradiol levels, transvaginal ultrasonography, and pituitary magnetic resonance imaging. Transsphenoidal surgery showed pituitary adenoma staining for LH in both patients.
Result(S):
Cabergoline was effective in reducing E(2) levels and decreasing ovarian size but ineffective in shrinking the pituitary adenomas.
Conclusion(S):
This is the first description of the effectiveness of cabergoline as the primary treatment of spontaneous ovarian hyperstimulation syndrome in patients with gonadotropin-producing pituitary adenomas.
