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  3. A Transient, Emt-linked Loss Of Basement Membranes Indicates Metastasis And Poor Survival In Colorectal Cancer.
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  3. A Transient, Emt-linked Loss Of Basement Membranes Indicates Metastasis And Poor Survival In Colorectal Cancer.

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A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer.

Simone Spaderna1, Otto Schmalhofer, Falk Hlubek

  • 1Department of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany.

Gastroenterology
|September 6, 2006

View abstract on PubMed

Summary
This summary is machine-generated.

Basement membrane loss at the invasive front of colorectal cancer (CRC) correlates with metastasis and poor survival. This transient loss, regulated by ZEB1 and epithelial-mesenchymal transition (EMT), offers a potential therapeutic target.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Basement membrane (BM) loss is linked to tumor malignancy.
  • Colorectal adenocarcinomas often retain BM but can still metastasize.

Purpose of the Study:

  • Investigate the role of BM turnover in colorectal cancer (CRC) progression.
  • Elucidate mechanisms and clinical relevance of BM changes in CRC.

Main Methods:

  • Analyzed BM component expression in human CRCs and cell lines.
  • Examined transcriptional regulation and clinical significance of BM changes.

Main Results:

  • BM is typically present in the main tumor mass but lost at invasive regions.
  • Selective BM loss at the invasive front predicts distant metastasis and survival.
  • BM is reexpressed in metastases, indicating transient, environment-regulated loss.
  • Loss involves down-regulated synthesis and is linked to epithelial-mesenchymal transition (EMT) via ZEB1 repression.

Conclusions:

  • Transient BM loss at the invasive front is a prognostic marker for metastasis and survival in CRC.
  • Targeting ZEB1 presents a potential therapeutic strategy to inhibit CRC metastasis.