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Updated: Jul 20, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Puberty and depression
Adrian Angold1, E Jane Costello
1Department of Psychiatry and Behavioral Sciences, Center for Developmental Epidemiology, Duke University Medical Center, Brightleaf Square, Suite 22, 905 West Main Street, Durham, NC 27701, USA. Adrian.angold@duke.edu
Abstract:
Unipolar depression only becomes more common in girls than boys after the age of 13, as a result of an increased incidence of depressive episodes in girls at that time. This article reviews evidence that links multiple dimensions of maturation in the hypothalamo-pituitary-gonadal axis with this phenomenon. Effects of developmental status and timing have been implicated, but few studies have deployed either the measurement strategies or the statistical power needed to provide a satisfactory answer to the question regarding which components of puberty are most responsible.
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