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Ventilator management protocols in pediatrics
Alan S Graham1, Aileen L Kirby
1Department of Pediatrics, Division of Pediatric Critical Care, Oregon Health & Science University, Mail Code CDRC-P, 707 SW Gaines Street, Portland, OR 97239-2901, USA. grahamal@ohsu.edu
Insights
Mechanical ventilation protocols show benefits in adults but are not routinely recommended for all pediatric patients. A multidisciplinary approach to best practices is crucial for optimizing outcomes in critically ill children.
Area of Science:
- Critical Care Medicine
- Pediatric Respiratory Medicine
- Evidence-Based Practice
Background:
- Mechanical ventilation management is complex, influenced by patient and caregiver factors.
- Protocols synthesize best evidence to improve outcomes like ventilation duration and complications in adults.
- Pediatric evidence does not uniformly support routine ventilator management protocols, possibly due to shorter weaning times.
Purpose of the Study:
- To review the evidence for mechanical ventilation management protocols in pediatric intensive care units (PICUs).
- To identify areas where protocols are beneficial, such as sedation titration and spontaneous breathing trials (SBTs).
- To explore the role of protocols in specific pediatric subpopulations and therapeutic trials.
Main Methods:
- Systematic review and synthesis of existing literature on mechanical ventilation protocols in pediatrics.
- Analysis of outcomes associated with protocolized care versus non-protocolized care.
- Identification of confounding factors affecting ventilator-related outcomes.
Main Results:
- Protocols improve outcomes in adults but are not universally adopted or successful in pediatrics.
- Evidence supports protocols for sedation titration and daily spontaneous breathing trials (SBTs) in pediatric patients.
- Nutrition, fluid balance, and specific conditions like congenital heart disease can influence outcomes.
Conclusions:
- Routine adoption of general ventilator management protocols is not recommended for all pediatric patients.
- A multidisciplinary team approach to developing best practices for mechanical ventilation is highly valuable.
- Further research is needed to define the precise role of protocols in the general PICU population.
Abstract:
Management of mechanical ventilation is a complex process with outcomes affected by multiple patient and caregiver variable. Well-constructed protocols represent the synthesis of best available evidence regarding ventilator management. In adults, protocols improve important outcomes such as duration of mechanical ventilation, length of stay, and complication rates; however, protocols are not uniformly successful. In pediatrics, the available evidence does not suggest that ventilator management protocols should be adopted routinely, which may be due to pediatric-specific attributes such as a generally shorter weaning duration. Evidence suggests support for protocols to carefully titrate sedation. In addition, daily assessment of SBTs improves patient outcomes and should be more uniformly adopted in pediatrics. Ventilator-related outcomes may be affected by other confounding factors such as nutrition and fluid balance. Specific subpopulations, such as children who have congenital heart disease, may present opportunities for focused use of ventilator management protocols. Protocolized ventilation has an important place in trials of new therapeutic strategies such as surfactant or proning. It is hoped that future research will further define the appropriate use of protocols in the general PICU population. Although specific protocols cannot be routinely recommended, a multidisciplinary team approach to synthesizing available literature and determining best practice is a useful model. This approach will foster "team ownership" of ventilator management by all involved, thus engendering the best possible outcomes for critically ill children who require mechanical ventilation.
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