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09:02
Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
[Perioperative management of coagulation]
1Universitätsklinik für Anästhesie und Allgemeine Intensivmedizin, Medizinische Universität Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria. Petra.Innerhofer@uibk.ac.at
Hamostaseologie
|September 6, 2006
Summary
Intraoperative hypocoagulability management guidelines need updating. This review discusses challenges with current transfusion practices and explores alternative strategies like coagulation factor concentrates for improved hemostatic therapy.
Area of Science:
- Anesthesiology and Critical Care Medicine
- Hematology
- Transfusion Medicine
Context:
- Intraoperative hypocoagulability management often relies on outdated transfusion guidelines.
- Standard laboratory assays may not accurately guide hemostatic therapy in the dynamic surgical setting.
- Recent changes in blood component preparation and volume therapy impact coagulopathy.
Purpose:
- To review the pathogenesis of intraoperative coagulopathy.
- To highlight limitations of current diagnostic and therapeutic recommendations.
- To explore advanced monitoring and alternative treatment strategies.
Summary:
- This article examines the pathophysiology of intraoperative bleeding disorders.
- It critically evaluates current transfusion triggers and the reliability of laboratory tests.
- The role of thromboelastographic monitoring and coagulation factor concentrates as alternatives to fresh frozen plasma (FFP) is discussed.
Impact:
- Provides a comprehensive overview of intraoperative hemostatic challenges.
- Suggests a shift towards more personalized and effective coagulopathy management.
- Highlights the potential of coagulation factor concentrates for improved patient outcomes.
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