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Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...

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Related Experiment Video

Updated: Jul 20, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
06:23

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

[Coagulation management during liver transplantation].

K Görlinger1

  • 1Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen. klaus@goerlinger.net

Hamostaseologie
|September 6, 2006
PubMed
Summary

Liver transplant patients often face bleeding or clotting issues. This study shows ROTEM monitoring allows targeted antifibrinolytic drug use, improving coagulation management during liver transplantation.

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Last Updated: Jul 20, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
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Published on: August 4, 2018

New Thrombectomy Technique for Total Portal Vein Thrombosis in Liver Transplantation
08:45

New Thrombectomy Technique for Total Portal Vein Thrombosis in Liver Transplantation

Published on: June 27, 2025

Area of Science:

  • Hepatology
  • Transplantation Medicine
  • Coagulation Science

Context:

  • Liver transplantation is associated with significant coagulation and bleeding disorders.
  • Perioperative thromboembolic events pose a fatal risk to transplant recipients.
  • Routine prophylaxis with antifibrinolytic drugs was discontinued in 1999.

Purpose:

  • To implement and evaluate the ROTEM system for perioperative point-of-care coagulation management in liver transplantation.
  • To refine coagulation management strategies by moving away from routine antifibrinolytic prophylaxis.

Summary:

  • Over 18,000 ROTEM measurements from 642 liver transplantations (2000-2005) were analyzed.
  • Antifibrinolytic drugs were reserved for fulminant liver failure or specific ROTEM parameters (MCF in ExTEM ≤35 mm).
  • Hyperfibrinolysis was detected in 60% of patients, but antifibrinolytic therapy was only required in 40%.

Impact:

  • Demonstrates the utility of ROTEM in guiding perioperative coagulation management for liver transplant patients.
  • Highlights the potential to reduce unnecessary antifibrinolytic drug administration.
  • Provides an algorithm for ROTEM-based management, optimizing patient outcomes and resource utilization.