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Updated: Jul 20, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Standardised uptake values from PET/CT images: comparison with conventional attenuation-corrected PET
M Souvatzoglou1, S I Ziegler, M J Martinez
1Nuklearmedizinische Klinik der Technischen Universität München, Ismaninger Strasse 22, 81675 Munich, Germany. msouvatz@t-online.de
Standardised uptake values (SUVs) from positron emission tomography/computed tomography (PET/CT) are comparable to stand-alone PET. This supports PET/CT
Area of Science:
- Nuclear medicine
- Medical imaging
- Oncology
Background:
- Positron emission tomography/computed tomography (PET/CT) combines functional and anatomical imaging.
- CT-derived attenuation correction in PET/CT may affect standardised uptake values (SUVs) compared to stand-alone PET.
- Accurate SUV quantification is crucial for cancer assessment.
Purpose of the Study:
- To compare intra-individual PET/CT-derived SUVs with stand-alone PET-derived SUVs.
- To evaluate the influence of CT attenuation correction on SUV measurements in various organs and tumour lesions.
- To validate findings using a phantom study.
Main Methods:
- Prospective study of 35 cancer patients undergoing both stand-alone PET and PET/CT scans.
- FDG PET scans performed on ECAT HR+ and Biograph Sensation 16 PET/CT scanners.
- Analysis of mean and maximum SUVs in lesions and organs (brain, lung, liver, spleen, bone).
- Phantom study using spheres and a cylinder to assess radioactivity concentration.
Main Results:
- Strong correlation between PET and PET/CT derived SUVs for lesions near (r=0.97) and far (r=0.87-0.89) from the diaphragm.
- No significant differences in SUVs calculated from PET versus PET/CT in lesions or organs.
- Phantom study showed significant correlation (r=0.99) for radioactivity concentration.
Conclusions:
- SUVs derived from PET/CT are comparable to those from stand-alone PET.
- PET/CT is a reliable tool for quantitative assessment of tumour metabolism.
- Findings support the clinical utility of PET/CT-derived SUVs in oncology.
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