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Conjunctival Splendore-Hoeppli phenomenon in a 3-year-old child
Diclehan Orhan1, Hayyam Kiratli, Sibel Kocabeyoğlu
1Hacettepe University Faculty of Medicine, Department of Ophthalmology, and Ihsan Doğramaci Children's Hospital, Ankara, Turkey. diclehan@hacettepe.edu.tr
Summary
A rare case of benign conjunctival granulomas in a child was linked to the Splendore-Hoeppli phenomenon. This finding suggests considering this condition for small conjunctival tumors in early childhood.
Area of Science:
- Ophthalmology
- Pathology
- Immunology
Background:
- The Splendore-Hoeppli phenomenon is a distinctive granulomatous reaction often associated with parasitic or fungal infections.
- While typically seen in adults, its occurrence in pediatric conjunctival lesions is less understood.
Observation:
- A case report details a 3-year-old girl with benign conjunctival granulomas.
- Histopathological examination of the excised lesions revealed features consistent with the Splendore-Hoeppli phenomenon.
Findings:
- No specific causative agent (parasite or fungus) was identified in the patient.
- Immunohistochemical analysis did not show reactivity for immunoglobulin G (IgG), IgM, IgA, or the C3 complement component.
Implications:
- The study suggests that small, amelanotic nodular conjunctival tumors in young children should raise suspicion for the Splendore-Hoeppli phenomenon.
- This highlights the importance of considering this phenomenon in the differential diagnosis of pediatric conjunctival masses, even without a clear infectious etiology.
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