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Fetal prostate growth and development.

T Xia1, W R Blackburn, W A Gardner

  • 1Department of Pathology, Beijing Medical University, China.

Pediatric Pathology
|January 11, 1990
PubMed
Summary
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This study details normal fetal and newborn prostate development, revealing distinct growth stages and secretory activity patterns. Prostate-specific antigen detection was weak and unrelated to secretion during this period.

Area of Science:

  • Urology
  • Developmental Biology
  • Histology

Background:

  • The prostate gland's development is crucial for male reproductive health.
  • Understanding early prostate growth and secretory function is essential for identifying potential developmental abnormalities.

Purpose of the Study:

  • To investigate the growth patterns, histogenesis, and secretory activity of normal fetal and newborn prostates.
  • To characterize the developmental stages of the human prostate from 20 weeks gestation to 1 month of age.

Main Methods:

  • Analysis of 107 whole cross-sectioned prostates from fetuses and newborns (20 weeks gestation to 1 month).
  • Histological examination using Periodic Acid-Schiff (PAS) and alcian blue-PAS staining to assess secretory activity.
  • Evaluation of squamous metaplasia and microcyst formation.

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  • Detection of prostate-specific antigen (PSA) and its relation to secretory activity.

    • Main Results:

    • Prostate development progresses through three distinct stages: bud (20-30 weeks), bud-tubule (31-36 weeks), and acinotubular (37-42 weeks gestation).
    • Secretory activity, indicated by PAS and alcian blue-PAS positivity, was observed in 65% of specimens by 20-30 weeks and over 87% by 37+ weeks gestation.
    • Squamous metaplasia and microcysts were noted in the urethra and ducts; PSA was weakly detected and not correlated with PAS-detected secretion.

    Conclusions:

    • Normal prostate development involves sequential stages with increasing secretory activity.
    • Early prostate secretory function is established prenatally, with PSA levels not directly correlating with this activity.
    • Findings provide a baseline for understanding normal prostate development and potential deviations.