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Molecular epidemiology of adenovirus isolates from patients diagnosed with intussusception in Melbourne, Australia
Gowri Selvaraj1, Carl Kirkwood, Julie Bines
1Enteric Virus Group, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Vicotria 3052, Australia.
Abstract:
Twenty-one intussusception (IS)-associated and 59 temporally linked adenoviral isolates from clinical infections were compared. Species C (15/21 IS- and 32/59 non-IS-associated isolates) dominated. Of these, serotype 2 (AdV-2) (7/15 IS-associated isolates) and serotype 1 (AdV-1) (16/32 non-IS-associated isolates) were the most commonly identified serotypes. DNA restriction analysis of AdV-2 isolates identified six genomic types; of these, type D2 (3/7 IS- and 8/11 non-IS-associated isolates) was the dominant type after BamHI and SmaI digestion. IS-associated isolates are similar to circulating non-IS-associated strains.
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