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Updated: Jul 20, 2026
04:32
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Ventilator-associated pneumonia caused by Dolosigranulum pigrum
A Hoedemaekers1, T Schülin, B Tonk
1Department of Intensive Care, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.
Journal of Clinical Microbiology
|September 7, 2006
Summary
Dolosigranulum pigrum, a rare bacterium, was identified in a patient with ventilator-associated pneumonia. Prompt antimicrobial treatment led to a successful patient recovery.
Area of Science:
- Microbiology
- Clinical Diagnostics
- Infectious Diseases
Background:
- Ventilator-associated pneumonia (VAP) poses significant clinical challenges.
- The identification of novel or unusual bacterial pathogens is crucial for effective VAP management.
Observation:
- Dolosigranulum pigrum, a gram-positive, catalase-negative coccus, was isolated from bronchial secretions.
- Prolonged incubation was required for the isolation of this unusual bacterium.
Findings:
- The patient diagnosed with VAP showed a positive response to antimicrobial therapy.
- 16S rRNA DNA sequence analysis confirmed the identification of Dolosigranulum pigrum.
- Simple phenotypic tests can also be utilized for its identification.
Implications:
- This case highlights Dolosigranulum pigrum as a potential pathogen in VAP.
- Effective antimicrobial therapy can be successful in treating infections caused by this bacterium.
- Further research into Dolosigranulum pigrum may improve diagnostic and treatment strategies for VAP.
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