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Updated: Jul 20, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Multicolor-FISH applied to resolve complex chromosomal changes in a case of T-ALL (FAB L2)
H Mkrtchyan1, M Glaser, M Gross
1Department of Genetic and Laboratory of Cytogenetics, State University, Jerewan, Armenia. hasmkrtambler.ru
Abstract:
We report on a patient with a clinically diagnosed acute lymphoblastic leukemia (ALL) with partial unrecorded complex translocation events especially involving chromosomes 5, 9 and 18. At the GTG-band level the karyotype was abnormal in 20% of the analyzed cells. The complex karyotype was studied in more detail by spectral karyotyping (SKY) and multicolor banding (MCB) to characterize it in more detail. Thus, the karyotype could be described very accurately and in summary three different clones were detected, reflecting a high rate of karyotypic evolution in this patient.
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