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Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
Published on: November 9, 2018
Longitudinal changes of cerebral glucose metabolism in semantic dementia
J Diehl-Schmid1, T Grimmer, A Drzezga
1Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany. janine.diehl@lrz.tum.de
Background:
Semantic dementia (SD).
Objective:
To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET).
Methods:
Eight patients with SD underwent (18)F-FDG-PET at baseline and at re-examination in average 15 months later.
Results:
Compared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05).
Conclusion:
Subtle functional changes suffice to produce significant neuropsycho- logical deterioration.
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