Serial diffusion-weighted magnetic resonance imaging in methanol intoxication
Hidemasa Takao1, Ippei Doi, Toshiaki Watanabe
1Department of Radiology, Showa General Hospital, Tokyo, Japan. takaoh-tky@umin.ac.jp
Abstract:
We report the serial magnetic resonance imaging (MRI) findings in a case of methanol intoxication. A 50-year-old man who had accidentally ingested methanol was admitted to our institution. The patient was almost blind, and became comatose. The MRI showed bilateral putaminal lesions with restricted diffusion. The MRI, which was performed on the third day after admission, showed new lesions in the subcortical white matter. The patient's general condition improved. His visual acuity, however, did not improve.
Insights
Methanol intoxication can cause severe brain damage, including bilateral putaminal lesions. Serial magnetic resonance imaging (MRI) revealed new white matter lesions, indicating progressive neurological injury despite clinical improvement.
Area of Science:
- Neurology
- Radiology
- Toxicology
Background:
- Methanol poisoning is a serious condition that can lead to significant neurological deficits.
- Prompt diagnosis and management are crucial to improve patient outcomes.
Observation:
- A 50-year-old male presented with visual impairment and coma after accidental methanol ingestion.
- Serial magnetic resonance imaging (MRI) was performed to evaluate the neurological effects.
Findings:
- Initial MRI demonstrated bilateral putaminal lesions with restricted diffusion, characteristic of methanol toxicity.
- Follow-up MRI revealed new lesions in the subcortical white matter, suggesting ongoing or secondary injury.
Implications:
- These findings highlight the utility of serial MRI in assessing the extent and progression of brain damage in methanol intoxication.
- The persistent visual deficits despite clinical improvement underscore the potential for long-term neurological sequelae.
