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Related Concept Videos

Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Spinal Cord01:26

Spinal Cord

The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Cellular Injury II: Classification01:21

Cellular Injury II: Classification

Cellular injury is any process that disrupts a cell’s ability to maintain homeostasis, leading to structural or functional changes. It is broadly classified based on etiology (cause) and mechanism of damage.Classification by EtiologyCellular injury may result from several causes. Hypoxic injury happens due to reduced oxygen delivery, most commonly from inadequate blood supply, such as arterial obstruction; for example, coronary artery thrombosis can cause myocardial infarction. Chemical injury...
Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...

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Related Experiment Video

Updated: Jul 20, 2026

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury
09:24

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

Published on: January 5, 2015

International Spinal Cord Injury Core Data Set.

M DeVivo1, F Biering-Sørensen, S Charlifue

  • 1Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, AL, USA.

Spinal Cord
|September 7, 2006
PubMed
Summary

The International Spinal Cord Injury (SCI) Core Data Set was developed through expert consensus to standardize patient data. This standardized data set aids in comparing spinal cord injury research globally.

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A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor
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A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor

Published on: July 24, 2012

Related Experiment Videos

Last Updated: Jul 20, 2026

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury
09:24

A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

Published on: January 5, 2015

A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor
07:28

A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor

Published on: July 24, 2012

Area of Science:

  • Neurology
  • Epidemiology
  • Rehabilitation Medicine

Background:

  • Standardized data collection is crucial for advancing spinal cord injury (SCI) research.
  • Previous research lacked a consistent methodology for collecting core patient information.
  • An international effort was needed to establish a unified data set for SCI studies.

Purpose of the Study:

  • To present the development and results of the International Spinal Cord Injury (SCI) Core Data Set.
  • To establish a standardized framework for collecting essential data in SCI research.
  • To facilitate global comparison of SCI patient populations and research outcomes.

Main Methods:

  • Convened an international expert committee to define essential data elements for the SCI Core Data Set.
  • Developed a draft data set and solicited feedback from relevant organizations.
  • Iteratively revised and disseminated the data set for final approval and adoption.

Main Results:

  • The International SCI Core Data Set comprises 24 key variables.
  • Variables include demographics, injury details (cause, fractures), treatment (surgery, dates), and functional status (neurological, ventilator).
  • The data set provides a comprehensive overview of patient characteristics.

Conclusions:

  • The International SCI Core Data Set should be a fundamental component of all future SCI studies.
  • Standardized data collection will enable accurate patient population descriptions.
  • Adoption of this data set will facilitate robust comparisons of SCI research findings worldwide.