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Metastatic atypical choroid plexus papilloma: a case report
Christopher E G Uff1, Malcolm Galloway, Robert Bradford
1Department of Neurosurgery, Royal Free Hospital, Hampstead, London, UK. chrisuff@hotmail.com
Journal of Neuro-Oncology
|September 7, 2006
Summary
Metastatic choroid plexus papilloma (CPP) is rare, but this case shows extensive neuraxis spread 3 years post-surgery. Treatment involved repeat surgery and craniospinal radiotherapy for this atypical tumor.
Area of Science:
- Neuro-oncology
- Pathology
Background:
- Choroid plexus papillomas (CPPs) are rare tumors in adults.
- Metastatic disease from CPPs is uncommon, usually associated with choroid plexus carcinoma.
Observation:
- A 32-year-old patient presented with multiple metastases along the neuraxis.
- These metastases appeared 3 years after resection of an atypical fourth ventricular CPP.
- Deposits spanned from the mid-brain to the lumbar cistern.
Findings:
- The patient underwent repeat surgery for the fourth ventricular tumor and a cervico-thoracic deposit.
- Craniospinal radiotherapy was administered.
- Diagnostic criteria for atypical CPP may be unclear, potentially leading to under-reporting.
Implications:
- This case highlights the possibility of extensive metastatic spread from atypical CPP.
- Reviews current literature on metastatic CPP.
- Discusses surgical and adjuvant therapy roles for typical and atypical CPP.