Related Experiment Video
Updated: Jul 20, 2026
14:18
Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
Published on: October 13, 2023
C1q nephropathy in association with Gitelman syndrome: a case report
Coral Hanevold1, Ayesa Mian, Rory Dalton
1Department of Pediatrics, Medical College of Georgia, BG 2071, 1120 15th St., Augusta, GA 30912-3795, USA. chanevol@mail.mcg.edu
Pediatric Nephrology (Berlin, Germany)
|September 7, 2006
Summary
Gitelman syndrome (GS) may be associated with C1q nephropathy (C1qN), a rare glomerular disease. Early proteinuria evaluation in GS patients is crucial for detecting this complication.
Area of Science:
- Nephrology
- Genetics
- Pathology
Background:
- Bartter syndrome (BS) and Gitelman syndrome (GS) are rare inherited tubulopathies.
- Glomerulopathies are infrequently reported in BS and GS patients.
Observation:
- A first-time case of C1q nephropathy (C1qN) is presented in an African American child with Gitelman syndrome (GS).
- The patient developed nephrotic-range proteinuria three years after GS diagnosis, with renal biopsy showing mesangial hypercellularity and FSGS.
Findings:
- Renal biopsy revealed C1q (2+) and IgG (1-2+) deposition in the mesangium with electron-dense deposits.
- Treatment with an ACE inhibitor reduced proteinuria but led to a decline in creatinine clearance.
Implications:
- This case suggests a potential association between Gitelman syndrome (GS) and glomerular diseases like C1q nephropathy (C1qN).
- Prompt proteinuria evaluation and renal biopsy are recommended for GS patients to identify glomerular pathology.
- Further research is needed to understand risk factors for this complication.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...