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The pattern of Down syndrome among children in Qatar: a population-based study

Atqah Abdul Wahab1, Abdulbari Bener, Amy L Sandridge

  • 1Department of Pediatrics, Hamad Medical Corporation , Hamad General Hospital, Doha, Qatar.

Birth Defects Research. Part A, Clinical and Molecular Teratology
|September 7, 2006
PubMed

Insights

Down Syndrome (DS) affects 19.5 per 10,000 live births in Qatar children under five. Regular trisomy is the most common abnormality, with congenital heart problems affecting half of affected children.

Area of Science:

  • Genetics
  • Pediatrics
  • Public Health

Background:

  • Retrospective descriptive study on Down Syndrome (DS) prevalence in children under five in Qatar.
  • Data collected from Hamad Medical Corporation hospitals over a six-year period (2000-2005).
  • 146 children diagnosed with DS during the study period.

Purpose of the Study:

  • Determine the prevalence pattern of Down Syndrome (DS) in children under five years of age in Qatar.
  • Analyze sociodemographic characteristics, genetic, and family history of DS cases.
  • Investigate the relationship between DS and maternal age.

Main Methods:

  • Diagnostic classification based on International Classification of Disease 10th Revision (ICD-10).
  • Review of medical records including sociodemographic data, genetic and family history, pedigree analysis, and clinical genetic examination.
  • Prevalence calculation per 10,000 live births.

Main Results:

  • Overall DS prevalence of 19.5 per 10,000 live births.
  • DS was more common in non-Qataris (59.6%) than Qataris (40.4%).
  • Higher frequency in infants under one year (40.4%), with regular trisomy (98%) and congenital heart problems (51.7%) being common.

Conclusions:

  • Identification of specific chromosomal abnormalities in DS is crucial for accurate genetic counseling.
  • Understanding recurrence risks and available options for parents is vital.
  • Significant relationship observed between DS and maternal age.
Abstract

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