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Updated: Jul 20, 2026

10:59
Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
Published on: August 21, 2021
DNA repair: from molecular mechanism to human disease
Errol C Friedberg1, Andres Aguilera, Martin Gellert
1Department of Pathology, University of Texas Southwestern, Medical Center at Dallas, 75390, USA.
DNA Repair
|September 7, 2006
Abstract
No abstract available in PubMed .
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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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