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Related Experiment Video

Updated: Jul 20, 2026

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Published on: May 20, 2016

Nasal airflow during respiratory cycle.

Seung-Kyu Chung¹, Young Rak Son, Seok Jae Shin

¹Department of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.

American Journal of Rhinology

|September 8, 2006

Summary

This study visualizes nasal airflow during breathing using a 3D model, revealing distinct flow patterns during inhalation and exhalation for a better understanding of nasal function.

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Area of Science:

Biomedical Engineering
Respiratory Physiology
Fluid Dynamics

Background:

Understanding nasal airflow patterns is crucial for comprehending nasal cavity function.
This study investigates the breath cycle of nasal airflow during resting respiration.

Purpose of the Study:

To observe and analyze nasal airflow patterns during the respiratory cycle.
To enhance the physiological understanding of nasal operations.

Main Methods:

A nasal cavity model was created using rapid prototyping from CT data.
A cam-driven piston pump simulated resting respiration.
Particle image velocimetry evaluated airflow, visualized in coronal images.

Main Results:

Maximal inspiratory velocity occurred at the nasal valve area, with airflow in middle and superior airways.
Expiratory airflow was primarily in the middle airway and slower than inspiratory flow.
Vortices were observed during the transition between inspiration and expiration.

Conclusions:

The findings expand knowledge of nasal airflow dynamics.
This technique offers a more physiological approach to understanding nasal operations.