Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Taste Buds and Receptors01:20

Taste Buds and Receptors

Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Personalized Selection of Inferior Turbinate Surgery Based on Structural Phenotyping: A Structured Narrative Review and Proposed Decision-Making Framework.

Journal of personalized medicine·2026
Same author

Tocilizumab but not Siltuximab prevents systemic inflammation in a humanized mouse model.

Frontiers in immunology·2026
Same author

Dietary habits and olfactory function in individuals with Parkinson's disease: an underexplored association.

Nutritional neuroscience·2026
Same author

Case report of Parkinson's disease in isolated congenital anosmia with absent olfactory bulbs.

NPJ Parkinson's disease·2026
Same author

ANCA-associated vasculitis is associated with an increased risk of cardiac and vascular morbidity: results of a large-scale propensity-matched global retrospective cohort study.

Frontiers in immunology·2026
Same author

Self-Reported Smell and Taste Disorders in the General Population: A Cross-Sectional Survey in Austria, Germany and Switzerland.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026

Related Experiment Video

Updated: Jul 20, 2026

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

Severe chemotherapy-induced parosmia.

Antje Müller1, Basile N Landis, Uwe Platzbecker

  • 1Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany. antje.mueller@uniklinikum-dresden.de

American Journal of Rhinology
|September 8, 2006
PubMed
Summary

Chemotherapy can cause parosmia, a smell disorder leading to severe weight loss. A simple nose clip effectively treated this olfactory dysfunction, restoring appetite and enabling weight gain.

Related Experiment Videos

Last Updated: Jul 20, 2026

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

Area of Science:

  • Oncology
  • Otolaryngology
  • Neuroscience

Background:

  • Chemotherapy and radiotherapy can cause smell and taste disorders.
  • While radiotherapy's effects on salivary glands and taste buds are understood, chemotherapy's impact on smell and taste remains unclear.
  • Patients undergoing chemotherapy often report quantitative olfactory loss (anosmia, hyposmia) rather than qualitative changes (parosmia, phantosmia).

Purpose of the Study:

  • To report a case of chemotherapy-induced parosmia.
  • To highlight the potential for parosmia to cause severe nutritional issues and life-threatening weight loss.
  • To emphasize the importance of recognizing and treating parosmia in chemotherapy patients.

Main Methods:

  • Case report of a 63-year-old woman experiencing chemotherapy-induced parosmia.
  • Utilized a simple nose clip to manage parosmia.
  • Monitored olfactory sensitivity, appetite, and weight over a 9-month period.

Main Results:

  • A nose clip successfully alleviated parosmia, allowing the patient to eat normally.
  • Olfactory sensitivity improved gradually over 9 months.
  • The patient experienced a progressive increase in appetite and weight.

Conclusions:

  • Parosmia is a rare but severe complication of chemotherapy that can be life-threatening.
  • This case underscores the necessity of olfactory testing and appropriate treatment for chemotherapy-induced olfactory dysfunction.
  • Prompt diagnosis and intervention are crucial for managing parosmia and preventing severe outcomes.