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Related Experiment Video

Updated: Jul 20, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Published on: April 28, 2023

Copper-associated chronic hepatitis in Labrador Retrievers.

G Hoffmann¹, T S G A M van den Ingh, P Bode

¹Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Netherlands. G.Hoffmann@vet.uu.nl

Journal of Veterinary Internal Medicine

|September 8, 2006

Summary

Hereditary copper-associated chronic hepatitis (CACH) in Labrador Retrievers is linked to a genetic defect in copper metabolism. This study found significantly higher liver copper levels in affected dogs, supporting a primary storage disease.

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Area of Science:

Veterinary Medicine
Genetics
Hepatology

Background:

Copper-associated chronic hepatitis (CACH) is a liver disease affecting Labrador Retrievers.
The exact cause of CACH in this breed is not fully understood, but a genetic component is suspected.

Purpose of the Study:

To investigate the clinical and pathological findings in Labrador Retrievers with CACH.
To test the hypothesis that CACH in this breed is caused by a genetic defect in hepatic copper metabolism.

Main Methods:

Clinical and pathological data from 15 Labrador Retrievers with CACH were summarized.
Liver biopsy specimens were examined histologically, including copper quantification.
Eight family members and six unrelated healthy Labrador Retrievers were also examined.

Main Results:

Affected dogs showed disproportionate increases in alanine aminotransferase (ALT) relative to alkaline phosphatase (ALP) activity.
Histopathology revealed centrolobular copper localization and accumulation associated with liver damage.
Mean hepatic copper concentration in affected dogs (1,317 µg/g) was significantly higher than in healthy controls (233 µg/g).

Conclusions:

The findings support a hereditary basis for CACH in Labrador Retrievers.
A defect in hepatic copper metabolism, likely genetic, is the probable cause of this condition.