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Updated: Jul 20, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Adenovirus subversion of immune surveillance, apoptotic and growth regulatory pathways: a model for tumorigenesis

Janet Strath1, G E Blair

  • 1Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.

Acta Microbiologica Et Immunologica Hungarica
|September 8, 2006
PubMed

Insights

Adenovirus offers a new model to study tumor progression by examining how it evades immune surveillance and disrupts cell growth. Understanding these mechanisms could lead to new cancer therapies.

Area of Science:

  • Virology
  • Cancer Biology
  • Immunology

Background:

  • Adenovirus serves as a model system for investigating tumor progression.
  • Like other DNA tumor viruses, adenovirus evades immune surveillance.
  • Adenovirus disrupts cellular apoptotic and growth regulatory pathways.

Purpose of the Study:

  • To evaluate the roles of multiple factors in tumor progression using the adenovirus model.
  • To understand adenovirus's strategies for immune evasion.
  • To investigate the subversion of cellular networks by adenovirus.

Main Methods:

  • Utilizing the adenovirus system as a model.
  • Analyzing viral strategies for immune evasion.
  • Investigating cellular network perturbations.

Main Results:

  • Adenovirus employs strategies to evade immune surveillance.
  • Adenovirus perturbs cellular apoptotic and growth regulatory pathways.
  • Cellular network subversion by adenovirus is similar to that in tumor cells.

Conclusions:

  • The adenovirus system is a valuable model for studying tumor progression.
  • Further uncovering adenovirus's immune evasion and cellular interference mechanisms is crucial.
  • These findings have potential ramifications for designing novel cancer therapeutics.

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