Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stabilizing daily clock proteins.

Hugh D Piggins1

  • 1Faculty of Life Sciences, University of Manchester, 3.614 Stopford Building, Oxford Road, Manchester M13 9PT, UK. hugh.piggins@manchester.ac.uk

The Biochemical Journal
|September 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-differential associations of MC3R p.F45S with human metabolic profile.

Journal of neuroendocrinology·2026
Same author

Beyond the barrier: an assessment of social behaviour in mice using a modified 3-chamber test.

Physiology & behavior·2026
Same author

Differential effects of sex and age on daily and infradian rhythms of mice.

The Journal of physiology·2026
Same author

Loss of neuropeptide signalling alters temporal expression of mouse suprachiasmatic neuronal state and excitability.

The European journal of neuroscience·2024
Same author

A novel developmental critical period of orexinergic signaling in the primary visual thalamus.

iScience·2024
Same author

Diverse genetic alteration dysregulates neuropeptide and intracellular signalling in the suprachiasmatic nuclei.

The European journal of neuroscience·2024
Same journal

Mechanistic insights into acetylated histone recognition by the CECR2 bromodomain.

The Biochemical journal·2026
Same journal

Nanobodies against Plasmodium adhesins that block receptor engagement and malaria parasite invasion.

The Biochemical journal·2026
Same journal

Persistence without turnover: the RhoG G12E mutant highlights the role of nucleotide cycling in RhoG signaling.

The Biochemical journal·2026
Same journal

Alternative Splicing of Rice Chloroplastic CuZn Superoxide Dismutase, OsCSD2: Impact on expression and protein characteristics.

The Biochemical journal·2026
Same journal

Difference and similarity between the ubiquitous secretory pathway Ca2+-ATPases, SERCA2b, and SPCA1a.

The Biochemical journal·2026
Same journal

A molecular perspective on dimethylarginine dimethylaminohydrolases structure and function.

The Biochemical journal·2026
See all related articles

Protein phosphatase 1 stabilizes the key circadian protein PER2 in mammals, advancing our understanding of biological timekeeping. This finding differs from fruitfly and fungal models, highlighting species-specific clock mechanisms.

Area of Science:

  • Chronobiology
  • Molecular Biology
  • Biochemistry

Background:

  • Biological timekeeping relies on internal programs and external cues.
  • Core genes of the mammalian circadian clock are known, but protein regulators remain unclear.
  • PER2 (Period 2) is a crucial protein in the core molecular clockworks.

Discussion:

  • Gallego et al. identify protein phosphatase 1 (PP1) as a key regulator of mammalian PER2 stability.
  • This finding contrasts with evidence in Drosophila and Neurospora, where protein phosphatase 2A is implicated.
  • The precise mechanisms by which PP1 influences PER2 stability require further elucidation.

Key Insights:

  • Protein phosphatase 1 directly impacts the stability of the mammalian PER2 protein.
  • This discovery offers new insights into the regulation of circadian rhythms in mammals.

Related Experiment Videos

  • Identifies a potential divergence in core clock regulatory mechanisms between mammals and other species.

    • Outlook:

    • Future research should focus on identifying the specific regulatory subunit of PP1 that targets mammalian PER2.
    • Understanding these interactions is crucial for a comprehensive model of mammalian circadian clock function.
    • Further studies may reveal novel therapeutic targets for circadian rhythm disorders.