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Contraceptive effect of sperm-agglutinating factor isolated from Staphylococcus aureus in mouse
1Department of Microbiology, Panjab University, Chandigarh, India.
Objective:
To investigate the contraceptive effect of sperm-agglutinating factor (SAF) isolated from Staphylococcus aureus in mouse.
Design:
Experimental study performed with LACA mice obtained from the Central Animal House, Panjab University, Chandigarh, India.
Setting:
In vivo studies conducted in the Department of Microbiology, Panjab University, Chandigarh, India.
Population:
Sixty female and 18 male mice were used for the studies.
Methods:
Mice sperm-S. aureus agglutination, scanning electron microscopy (SEM), in vivo studies in mice.
Main Outcome Measure:
Contraceptive efficacy of SAF.
Results:
S. aureus readily adhered to and agglutinated mouse spermatozoa. By SEM, S. aureus adherence was observed on sperm head as well as sperm tail. SAF was found to be causing 100% fertility inhibition in mouse with no effect on vaginal epithelium.
Conclusions:
Sperm-agglutinating factor has been found to have a potential as a contraceptive agent.
