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Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

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A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
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Microorganisms play a crucial role in agriculture and the food industry, contributing to soil fertility, crop protection, and food production. Their functions range from nitrogen fixation and biopesticide production to fermentation and food preservation, making them indispensable to sustainable farming and food safety.Role in AgricultureNitrogen-fixing bacteria, such as Rhizobium (symbiotic) and Azotobacter (free-living), convert atmospheric nitrogen into ammonia through biological nitrogen...
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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Related Experiment Video

Updated: Feb 14, 2026

Basophil Activation Test for Allergy Diagnosis
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[Food allergy in children].

E Bidat1

  • 1Service de Pédiatrie, Hôpital Ambroise-Paré, 9, avenue du Général-de-Gaulle, 92104 Boulogne cedex, France. e.bidat@wanadoo.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|September 8, 2006
PubMed
Summary

Food allergy involves immunological reactions to food proteins, often manifesting as atopic dermatitis in children. Diagnosis uses clinical history and tests, with treatment focusing on dietary avoidance and potential desensitization.

Area of Science:

  • Immunology
  • Pediatrics
  • Dermatology

Context:

  • Food allergy is a significant health concern, particularly in pediatric populations.
  • Atopic dermatitis is a primary clinical manifestation of food allergy.
  • Specific allergens like cow's milk and hen's eggs are common in children in regions like France.

Purpose:

  • To outline the immunological mechanisms of food allergy.
  • To describe the diagnostic approaches for food allergy.
  • To detail current treatment strategies and emerging therapies for food allergy.

Summary:

  • Food allergy is an immune response to food proteins, categorized as IgE or non-IgE mediated.
  • Clinical signs can affect multiple organs, with atopic dermatitis being the most frequent.

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  • Diagnosis involves clinical history, skin prick tests, specific IgE measurements, and potentially oral food challenges.
  • Management centers on strict dietary avoidance, which can be total or partial, and sometimes includes raw food restrictions.
  • Spontaneous tolerance can develop, and ongoing research explores food desensitization.

    • Impact:

    • Provides a comprehensive overview of food allergy for clinicians and researchers.
    • Highlights the importance of accurate diagnosis and tailored management plans.
    • Informs the development of new therapeutic interventions, including immunotherapy.