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The association between subclinical hyperthyroidism and blood pressure in a population-based study
Henry Völzke1, Dietrich Alte, Marcus Dörr
1Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University, Walther Rathenau Str. 48, D-17487 Greifswald, Germany. voelzke@uni-greifswald.de
Journal of Hypertension
|September 8, 2006
Summary
Subclinical hyperthyroidism, indicated by low or suppressed thyrotropin levels, is not linked to hypertension. This population-based study found no significant association between thyroid function and blood pressure in individuals without overt thyroid disease.
Area of Science:
- Endocrinology
- Cardiovascular Health
- Thyroid Research
Background:
- Overt hyperthyroidism and hypothyroidism are linked to hypertension.
- The relationship between subclinical hyperthyroidism and blood pressure requires further investigation.
Purpose of the Study:
- To examine the association between subclinical hyperthyroidism and blood pressure in a large population sample.
- To determine if decreased or suppressed serum thyrotropin levels correlate with hypertension.
Main Methods:
- Population-based study (Study of Health in Pomerania) in Germany.
- 4087 participants without overt thyroid disease analyzed.
- Serum thyrotropin levels categorized as decreased (< 0.25 mIU/l) or suppressed (< 0.1 mIU/l).
Main Results:
- Lower adjusted mean systolic blood pressure observed in subjects with decreased thyrotropin levels compared to normal levels (P=0.04).
- No significant differences in diastolic or pulse pressure between groups.
- Exclusion of subjects on antihypertensive medication revealed no significant associations.
Conclusions:
- Subclinical hyperthyroidism, defined by low or suppressed thyrotropin levels, is not associated with hypertension.
- Thyroid hormone levels within the reference range do not appear to influence blood pressure in subclinical hyperthyroidism.
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