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Updated: Jul 20, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

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Published on: August 11, 2019

Early presynaptic changes during plasticity in cultured hippocampal neurons

Ipe Ninan1, Shumin Liu, Daniel Rabinowitz

  • 1Taub Institute and Department of Pathology, Columbia University, New York City, NY 10032, USA.

The EMBO Journal
|September 8, 2006
PubMed
Summary

Synaptic potentiation, crucial for learning, involves presynaptic (prS) terminal remodeling. New release sites form, and existing ones increase release probability, preceding postsynaptic (pstS) AMPA receptor changes.

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Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.