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Published on: September 23, 2015
The serotonin receptor HTR1B: gene polymorphisms in attention deficit hyperactivity disorder
Abel Ickowicz1, Yu Feng, Karen Wigg
1The Hospital for Sick Children, Toronto, Ontario, Canada. abel.ickowicz@sickkids.ca
Summary
This study found no association between the HTR1B gene and attention deficit hyperactivity disorder (ADHD) or perfectionism in families with ADHD. Genetic analysis did not support a link between HTR1B polymorphisms and ADHD traits or obsessive behaviors.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Serotonin influences cognition, mood, and behavior.
- HTR1B gene polymorphisms are linked to psychiatric disorders like ADHD and OCD.
Purpose of the Study:
- Investigate the association between the HTR1B gene and ADHD.
- Examine the link between HTR1B and obsessive behaviors/perfectionism in ADHD families.
Main Methods:
- Genotyped six single nucleotide polymorphisms (SNPs) of the HTR1B gene.
- Analyzed 203 families with an ADHD proband using TDT and haplotype analysis.
Main Results:
- No significant association found between HTR1B gene and ADHD diagnosis or quantitative traits (inattentive, hyperactive-impulsive).
- No evidence of association between HTR1B gene and perfectionism in the studied ADHD sample.
Conclusions:
- The HTR1B gene is not associated with ADHD or perfectionism in this cohort.
- Further research may be needed to explore other genetic factors in ADHD and related obsessive traits.
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