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Alcohol and lipid metabolism

David W Crabb1, Suthat Liangpunsakul

  • 1Indiana Alcohol Research Center, Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA. dcrabb@iupui.edu

Journal of Gastroenterology and Hepatology
|September 9, 2006
PubMed
Summary

Chronic ethanol exposure disrupts hepatic lipid metabolism by inhibiting PPAR-alpha and AMPK, while activating SREBP-1. This affects fatty acid transport and oxidation, with underlying mechanisms requiring further investigation.

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