Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Epistasis01:39

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
Pedigree Analysis01:35

Pedigree Analysis

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multifocal Cutaneous Abscesses.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

Unraveling Centrofacial Swelling: A Clinicopathological Perspective of Tumid Lupus Erythematosus.

Indian dermatology online journal·2026
Same author

Facial and Scalp Ulceration: Unveiling the Hidden Pathology of Congenital Cytomegalovirus Infection.

International journal of dermatology·2026
Same author

Tryptanthrin: Synthetic advances and therapeutic horizons of a privileged scaffold.

European journal of medicinal chemistry·2026
Same author

Exploring novel resistant sources for chilli leaf curl disease in Capsicum annuum L. germplasm for genetic enhancement.

Scientific reports·2026
Same author

A rapidly growing perianal nodule associated with diffuse hyperpigmentation in a neonate.

Clinical and experimental dermatology·2025

Related Experiment Video

Updated: Jul 20, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Familial pigmented purpuric dermatoses.

Gomathy Sethuraman1, Selvendran Sugandhan, Arika Bansal

  • 1Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India. kgsethu@yahoo.com

The Journal of Dermatology
|September 9, 2006
PubMed
Summary

Familial occurrence of pigmented purpuric dermatoses (PPD) is rare. This study documents four PPD cases across three generations in one family, suggesting an autosomal dominant inheritance pattern for these chronic skin conditions.

More Related Videos

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

Related Experiment Videos

Last Updated: Jul 20, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

Area of Science:

  • Dermatology
  • Genetics

Background:

  • Pigmented purpuric dermatoses (PPD) are a group of chronic, typically asymptomatic skin conditions.
  • PPD are characterized clinically by petechiae, pigmentation, and occasionally telangiectasias.

Observation:

  • Familial clustering of PPD is exceptionally uncommon in medical literature.
  • This report details a family with four affected individuals spanning three generations.

Findings:

  • The observed pattern of PPD occurrence within the family suggests a potential genetic link.
  • Inheritance appears to follow an autosomal dominant transmission pattern.

Implications:

  • Understanding the genetic basis of PPD can aid in diagnosis and genetic counseling.
  • Further research into familial PPD may reveal specific genes or mutations responsible for the condition.