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RNA synthesis by hepatocytes isolated from adult and senescent Wistar rat liver
1Department of Physiology and Biophysics, University of Illinois, Urbana.
Gerontology
|January 1, 1990
Abstract:
The rates of synthesis of total RNA, poly(A)+ RNA and poly(A)+ RNA are decreased by 41, 49 and 42%, respectively, in hepatocytes isolated from senescent (25 months) compared to adult (12 months) female Wistar rats. Results from transcription run-on assays indicate that an impaired ability to initiate transcription largely accounts for the decreased synthesis of RNA by the senescent hepatocytes.