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Related Concept Videos

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Related Experiment Video

Updated: Jul 13, 2026

Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability
09:49

Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability

Published on: April 2, 2015

Targeting protein stability with a small molecule.

Michael A Lampson1, Tarun M Kapoor

  • 1Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10021, USA.

Cell
|September 9, 2006
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel method to control protein stability using a genetically encoded tag and a small molecule for temporal regulation. This approach offers precise control over protein function for biological studies.

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Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
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Related Experiment Videos

Last Updated: Jul 13, 2026

Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability
09:49

Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability

Published on: April 2, 2015

How to Stabilize Protein: Stability Screens for Thermal Shift Assays and Nano Differential Scanning Fluorimetry in the Virus-X Project
07:22

How to Stabilize Protein: Stability Screens for Thermal Shift Assays and Nano Differential Scanning Fluorimetry in the Virus-X Project

Published on: February 11, 2019

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11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Chemical Biology

Background:

  • Genetic and small-molecule methods are established for perturbing protein function.
  • Controlling protein stability offers an alternative strategy for functional studies.

Discussion:

  • Banaszynski et al. present a technique combining genetic encoding and small molecules.
  • This method allows for specific targeting and temporal control of protein degradation.

Key Insights:

  • A genetically encoded tag confers specificity to the target protein.
  • A small molecule provides temporal control over protein stability regulation.

Outlook:

  • This strategy enhances the toolkit for studying protein function.
  • Potential applications in chemical genetics and drug discovery.