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Protein Glycosylation

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...

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Related Experiment Video

Updated: Apr 1, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

Chemical technologies for probing glycans.

Jennifer A Prescher¹, Carolyn R Bertozzi

¹Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.

|September 9, 2006

Summary

Chemical tools are emerging to help scientists understand the crucial roles of glycans in biological processes. These new technologies overcome previous limitations in studying these complex carbohydrates at a molecular level.

Area of Science:

Carbohydrate Chemistry
Molecular Biology
Biotechnology

Background:

Glycans play essential roles in numerous biological processes.
Understanding glycan function at the molecular level is critical for biological insights.
Previous technological limitations have hindered detailed glycan research.

Purpose of the Study:

To highlight novel chemical tools for glycan research.
To address the need for advanced technologies in glycobiology.
To facilitate the molecular-level study of glycan functions.

Main Methods:

Review of recent advancements in chemical technologies.
Focus on chemical tools enabling glycan analysis.
Highlighting innovative approaches in glycobiology.

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A Quantitative Glycomics and Proteomics Combined Purification Strategy

A Quantitative Glycomics and Proteomics Combined Purification Strategy

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Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases

Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases

Published on: December 26, 2011

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Last Updated: Apr 1, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

A Quantitative Glycomics and Proteomics Combined Purification Strategy

A Quantitative Glycomics and Proteomics Combined Purification Strategy

Published on: March 8, 2016

Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases

Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases

Published on: December 26, 2011

Main Results:

Emerging chemical tools are becoming available for glycan research.
These tools offer new possibilities for studying glycan functions.
Technological advancements are overcoming previous research barriers.

Conclusions:

Chemical tools are crucial for advancing glycobiology.
New technologies are enabling deeper molecular understanding of glycans.
The development of these tools is vital for future biological discoveries.