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Polycystic ovarian syndrome: the next cardiovascular dilemma in women?

Preethi Srikanthan1, Stanley Korenman, Susan Davis

  • 1Department of Epidemiology and Preventative Medicine, University of California Los Angeles, Box 957065, 330 South Garfield Avenue, Suite 308, Los Angeles, CA 90095, USA.

Endocrinology and Metabolism Clinics of North America
|September 9, 2006
PubMed

Insights

Women with polycystic ovary syndrome (PCOS) face higher cardiovascular disease risks. Addressing the cluster of risk factors in PCOS is key for prevention and therapy.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Reproductive Health

Background:

  • Polycystic ovary syndrome (PCOS) is associated with increased risks for cardiovascular disease (CVD).
  • PCOS presents with symptoms like amenorrhea, hirsutism, and obesity.
  • Familial studies indicate a predisposition to PCOS, diabetes, hypertension, and CVD.

Purpose of the Study:

  • To highlight the multifaceted cardiovascular risks in women with PCOS.
  • To discuss the diagnostic and research challenges posed by PCOS heterogeneity.
  • To propose a focus on the combined cardiovascular risk milieu for preventative strategies.

Main Methods:

  • Review of epidemiologic studies and clinical observations in PCOS patients.
  • Analysis of the co-existence of cardiovascular risk factors within the PCOS population.
  • Discussion of the role of insulin resistance and other contributing factors.

Main Results:

  • All known cardiovascular disease risks are elevated in women with PCOS.
  • A familial link exists between PCOS and conditions such as diabetes, hypertension, and CVD.
  • Phenotypic heterogeneity complicates diagnosis and research.

Conclusions:

  • Insulin resistance is a significant factor in some PCOS cases.
  • The concurrent presence of multiple CVD risk factors in PCOS patients creates a critical milieu.
  • Targeting this overall risk milieu is a promising strategy for prevention and therapy in PCOS.

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